diff --git a/cmd/prometheus/main.go b/cmd/prometheus/main.go
index 4c3ede362e..a9b3fd8ed9 100644
--- a/cmd/prometheus/main.go
+++ b/cmd/prometheus/main.go
@@ -352,7 +352,7 @@ func main() {
 	a.Flag("config.auto-reload-interval", "Specifies the interval for checking and automatically reloading the Prometheus configuration file upon detecting changes.").
 		Default("30s").SetValue(&cfg.autoReloadInterval)
 
-	a.Flag("web.listen-address", "Address to listen on for UI, API, and telemetry. Can be repeated.").
+	a.Flag("web.listen-address", "Address or UNIX domain socket path (prefixed with `unix://`) to listen on for UI, API, and telemetry. Can be repeated.").
 		Default("0.0.0.0:9090").StringsVar(&cfg.web.ListenAddresses)
 
 	a.Flag("auto-gomaxprocs", "Automatically set GOMAXPROCS to match Linux container CPU quota").
diff --git a/cmd/prometheus/main_test.go b/cmd/prometheus/main_test.go
index 0d0ab56eb4..f70b19c3d0 100644
--- a/cmd/prometheus/main_test.go
+++ b/cmd/prometheus/main_test.go
@@ -431,6 +431,50 @@ func TestAgentSuccessfulStartup(t *testing.T) {
 	require.Equal(t, 0, actualExitStatus)
 }
 
+func TestSuccessfulStartupWithUnixSocket(t *testing.T) {
+	socket := "prometheus-test.sock"
+
+	prom := exec.Command(promPath, "-test.main", "--web.listen-address=unix://"+socket, "--config.file="+promConfig)
+	require.NoError(t, prom.Start())
+
+	actualExitStatus := 0
+	done := make(chan error, 1)
+
+	go func() { done <- prom.Wait() }()
+	select {
+	case err := <-done:
+		out, outerr := prom.Output()
+		t.Logf("prometheus should be still running: %v %v %v", err, out, outerr)
+		actualExitStatus = prom.ProcessState.ExitCode()
+	case <-time.After(startupTime):
+		prom.Process.Kill()
+	}
+	os.Remove(socket)
+	require.Equal(t, 0, actualExitStatus)
+}
+
+func TestSuccessfulStartupWithUnixSocketAndExternalUrl(t *testing.T) {
+	socket := "prometheus-test.sock"
+
+	prom := exec.Command(promPath, "-test.main", "--web.external-url=https://example.com", "--web.listen-address=unix://"+socket, "--config.file="+promConfig)
+	require.NoError(t, prom.Start())
+
+	actualExitStatus := 0
+	done := make(chan error, 1)
+
+	go func() { done <- prom.Wait() }()
+	select {
+	case err := <-done:
+		out, outerr := prom.Output()
+		t.Logf("prometheus should be still running: %v %v %v", err, out, outerr)
+		actualExitStatus = prom.ProcessState.ExitCode()
+	case <-time.After(startupTime):
+		prom.Process.Kill()
+	}
+	os.Remove(socket)
+	require.Equal(t, 0, actualExitStatus)
+}
+
 func TestAgentFailedStartupWithServerFlag(t *testing.T) {
 	t.Parallel()
 
diff --git a/docs/command-line/prometheus.md b/docs/command-line/prometheus.md
index ebd6007f7b..8a69fc94af 100644
--- a/docs/command-line/prometheus.md
+++ b/docs/command-line/prometheus.md
@@ -16,7 +16,7 @@ The Prometheus monitoring server
 | <code class="text-nowrap">--version</code> | Show application version. |  |
 | <code class="text-nowrap">--config.file</code> | Prometheus configuration file path. | `prometheus.yml` |
 | <code class="text-nowrap">--config.auto-reload-interval</code> | Specifies the interval for checking and automatically reloading the Prometheus configuration file upon detecting changes. | `30s` |
-| <code class="text-nowrap">--web.listen-address</code> <code class="text-nowrap">...<code class="text-nowrap"> | Address to listen on for UI, API, and telemetry. Can be repeated. | `0.0.0.0:9090` |
+| <code class="text-nowrap">--web.listen-address</code> <code class="text-nowrap">...<code class="text-nowrap"> | Address or UNIX domain socket path (prefixed with `unix://`) to listen on for UI, API, and telemetry. Can be repeated. | `0.0.0.0:9090` |
 | <code class="text-nowrap">--auto-gomaxprocs</code> | Automatically set GOMAXPROCS to match Linux container CPU quota | `true` |
 | <code class="text-nowrap">--auto-gomemlimit</code> | Automatically set GOMEMLIMIT to match Linux container or system memory limit | `true` |
 | <code class="text-nowrap">--auto-gomemlimit.ratio</code> | The ratio of reserved GOMEMLIMIT memory to the detected maximum container or system memory | `0.9` |
diff --git a/web/web.go b/web/web.go
index 84c4a2a529..55c3b54764 100644
--- a/web/web.go
+++ b/web/web.go
@@ -651,11 +651,20 @@ func (h *Handler) Listeners() ([]net.Listener, error) {
 	return listeners, nil
 }
 
+// tcpOrUnixDomainSocket returns either TCP/IP or UNIX domain binding information.
+func tcpOrUnixDomainSocket(address string) (string, string) {
+	if strings.HasPrefix(address, "unix://") {
+		return "unix", strings.Replace(address, "unix://", "", 1)
+	}
+
+	return "tcp", address
+}
+
 // Listener creates the TCP listener for web requests.
 func (h *Handler) Listener(address string, sem chan struct{}) (net.Listener, error) {
 	h.logger.Info("Start listening for connections", "address", address)
 
-	listener, err := net.Listen("tcp", address)
+	listener, err := net.Listen(tcpOrUnixDomainSocket(address))
 	if err != nil {
 		return listener, err
 	}