diff --git a/web/ui/module/codemirror-promql/src/client/prometheus.test.ts b/web/ui/module/codemirror-promql/src/client/prometheus.test.ts
new file mode 100644
index 0000000000..c872edbb69
--- /dev/null
+++ b/web/ui/module/codemirror-promql/src/client/prometheus.test.ts
@@ -0,0 +1,97 @@
+// Copyright 2025 The Prometheus Authors
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+// http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+import { HTTPPrometheusClient, CachedPrometheusClient } from './prometheus';
+
+describe('HTTPPrometheusClient destroy', () => {
+  it('should be safe to call destroy multiple times', () => {
+    const client = new HTTPPrometheusClient({ url: 'http://localhost:8080' });
+    // First call
+    client.destroy();
+    // Second call should not throw
+    expect(() => client.destroy()).not.toThrow();
+  });
+
+  it('should abort in-flight requests when destroy is called', async () => {
+    let abortSignal: AbortSignal | null | undefined;
+
+    const mockFetch = (_url: RequestInfo, init?: RequestInit): Promise<Response> => {
+      abortSignal = init?.signal;
+      // Return a promise that never resolves to simulate an in-flight request
+      return new Promise(() => {});
+    };
+
+    const client = new HTTPPrometheusClient({
+      url: 'http://localhost:8080',
+      fetchFn: mockFetch,
+    });
+
+    // Start a request (don't await it)
+    client.labelNames();
+
+    // Verify the signal was captured and not aborted yet
+    expect(abortSignal).toBeDefined();
+    expect(abortSignal?.aborted).toBe(false);
+
+    // Destroy the client
+    client.destroy();
+
+    // Verify the request was aborted
+    expect(abortSignal?.aborted).toBe(true);
+  });
+});
+
+describe('CachedPrometheusClient destroy', () => {
+  it('should be safe to call destroy multiple times', () => {
+    const httpClient = new HTTPPrometheusClient({ url: 'http://localhost:8080' });
+    const cachedClient = new CachedPrometheusClient(httpClient);
+
+    // First call
+    cachedClient.destroy();
+    // Second call should not throw
+    expect(() => cachedClient.destroy()).not.toThrow();
+  });
+
+  it('should call destroy on the underlying HTTPPrometheusClient', () => {
+    const httpClient = new HTTPPrometheusClient({ url: 'http://localhost:8080' });
+
+    let destroyCalled = false;
+    const originalDestroy = httpClient.destroy.bind(httpClient);
+    httpClient.destroy = () => {
+      destroyCalled = true;
+      originalDestroy();
+    };
+
+    const cachedClient = new CachedPrometheusClient(httpClient);
+    cachedClient.destroy();
+
+    expect(destroyCalled).toBe(true);
+  });
+
+  it('should handle underlying clients without destroy method', () => {
+    // Create a minimal PrometheusClient without destroy
+    const minimalClient = {
+      labelNames: () => Promise.resolve([]),
+      labelValues: () => Promise.resolve([]),
+      metricMetadata: () => Promise.resolve({}),
+      series: () => Promise.resolve([]),
+      metricNames: () => Promise.resolve([]),
+      flags: () => Promise.resolve({}),
+    };
+
+    const cachedClient = new CachedPrometheusClient(minimalClient);
+
+    // Should not throw even though underlying client has no destroy
+    expect(() => cachedClient.destroy()).not.toThrow();
+  });
+});
diff --git a/web/ui/module/codemirror-promql/src/client/prometheus.ts b/web/ui/module/codemirror-promql/src/client/prometheus.ts
index 165549ac82..91de148f3c 100644
--- a/web/ui/module/codemirror-promql/src/client/prometheus.ts
+++ b/web/ui/module/codemirror-promql/src/client/prometheus.ts
@@ -39,6 +39,9 @@ export interface PrometheusClient {
 
   // flags returns flag values that prometheus was configured with.
   flags(): Promise<Record<string, string>>;
+
+  // destroy is called to release all resources held by this client
+  destroy?(): void;
 }
 
 export interface CacheConfig {
@@ -88,6 +91,7 @@ export class HTTPPrometheusClient implements PrometheusClient {
   // when calling it, thus the indirection via another function wrapper.
   private readonly fetchFn: FetchFn = (input: RequestInfo, init?: RequestInit): Promise<Response> => fetch(input, init);
   private requestHeaders: Headers = new Headers();
+  private readonly abortControllers: Set<AbortController> = new Set<AbortController>();
 
   constructor(config: PrometheusConfig) {
     this.url = config.url ? config.url : '';
@@ -199,11 +203,22 @@ export class HTTPPrometheusClient implements PrometheusClient {
     });
   }
 
+  destroy(): void {
+    for (const controller of this.abortControllers) {
+      controller.abort();
+    }
+    this.abortControllers.clear();
+  }
+
   private fetchAPI<T>(resource: string, init?: RequestInit): Promise<T> {
+    const controller = new AbortController();
+    this.abortControllers.add(controller);
+
     if (init) {
       init.headers = this.requestHeaders;
+      init.signal = controller.signal;
     } else {
-      init = { headers: this.requestHeaders };
+      init = { headers: this.requestHeaders, signal: controller.signal };
     }
     return this.fetchFn(this.url + resource, init)
       .then((res) => {
@@ -221,6 +236,9 @@ export class HTTPPrometheusClient implements PrometheusClient {
           throw new Error('missing "data" field in response JSON');
         }
         return apiRes.data;
+      })
+      .finally(() => {
+        this.abortControllers.delete(controller);
       });
   }
 
@@ -448,4 +466,8 @@ export class CachedPrometheusClient implements PrometheusClient {
       return flags;
     });
   }
+
+  destroy(): void {
+    this.client.destroy?.();
+  }
 }
diff --git a/web/ui/module/codemirror-promql/src/complete/hybrid.ts b/web/ui/module/codemirror-promql/src/complete/hybrid.ts
index bb5f4d9d36..fc79b6fcd6 100644
--- a/web/ui/module/codemirror-promql/src/complete/hybrid.ts
+++ b/web/ui/module/codemirror-promql/src/complete/hybrid.ts
@@ -575,6 +575,10 @@ export class HybridComplete implements CompleteStrategy {
     return this.prometheusClient;
   }
 
+  destroy(): void {
+    this.prometheusClient?.destroy?.();
+  }
+
   promQL(context: CompletionContext): Promise<CompletionResult | null> | CompletionResult | null {
     const { state, pos } = context;
     const tree = syntaxTree(state).resolve(pos, -1);
diff --git a/web/ui/module/codemirror-promql/src/complete/index.ts b/web/ui/module/codemirror-promql/src/complete/index.ts
index b3902c3b6b..dd73857639 100644
--- a/web/ui/module/codemirror-promql/src/complete/index.ts
+++ b/web/ui/module/codemirror-promql/src/complete/index.ts
@@ -19,6 +19,7 @@ import { CompletionContext, CompletionResult } from '@codemirror/autocomplete';
 // Every different completion mode must implement this interface.
 export interface CompleteStrategy {
   promQL(context: CompletionContext): Promise<CompletionResult | null> | CompletionResult | null;
+  destroy?(): void;
 }
 
 // CompleteConfiguration should be used to customize the autocompletion.
diff --git a/web/ui/module/codemirror-promql/src/promql.test.ts b/web/ui/module/codemirror-promql/src/promql.test.ts
new file mode 100644
index 0000000000..787747cc5e
--- /dev/null
+++ b/web/ui/module/codemirror-promql/src/promql.test.ts
@@ -0,0 +1,58 @@
+// Copyright 2025 The Prometheus Authors
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+// http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+import { PromQLExtension } from './promql';
+import { CompleteStrategy } from './complete';
+import { CompletionResult } from '@codemirror/autocomplete';
+
+describe('PromQLExtension destroy', () => {
+  it('should be safe to call destroy multiple times', () => {
+    const extension = new PromQLExtension();
+    // First call
+    extension.destroy();
+    // Second call should not throw
+    expect(() => extension.destroy()).not.toThrow();
+  });
+
+  it('should call destroy on the complete strategy if available', () => {
+    const extension = new PromQLExtension();
+
+    // Set up a mock complete strategy with destroy
+    let destroyCalled = false;
+    const mockCompleteStrategy: CompleteStrategy = {
+      promQL: (): CompletionResult | null => null,
+      destroy: () => {
+        destroyCalled = true;
+      },
+    };
+
+    extension.setComplete({ completeStrategy: mockCompleteStrategy });
+    extension.destroy();
+
+    expect(destroyCalled).toBe(true);
+  });
+
+  it('should handle complete strategies without destroy method', () => {
+    const extension = new PromQLExtension();
+
+    // Set up a mock complete strategy without destroy
+    const mockCompleteStrategy: CompleteStrategy = {
+      promQL: (): CompletionResult | null => null,
+    };
+
+    extension.setComplete({ completeStrategy: mockCompleteStrategy });
+
+    // Should not throw even though complete strategy has no destroy
+    expect(() => extension.destroy()).not.toThrow();
+  });
+});
diff --git a/web/ui/module/codemirror-promql/src/promql.ts b/web/ui/module/codemirror-promql/src/promql.ts
index 506cd1348b..859442559f 100644
--- a/web/ui/module/codemirror-promql/src/promql.ts
+++ b/web/ui/module/codemirror-promql/src/promql.ts
@@ -79,6 +79,10 @@ export class PromQLExtension {
     return this;
   }
 
+  destroy(): void {
+    this.complete.destroy?.();
+  }
+
   asExtension(languageType = LanguageType.PromQL): Extension {
     const language = promQLLanguage(languageType);
     let extension: Extension = [language];