diff --git a/reg-tests/connection/http_reuse_always.vtc b/reg-tests/connection/http_reuse_always.vtc
index 8f70367f8..75e60d4d4 100644
--- a/reg-tests/connection/http_reuse_always.vtc
+++ b/reg-tests/connection/http_reuse_always.vtc
@@ -1,3 +1,4 @@
+#EXCLUDE_TARGETS=osx
 varnishtest "Test the http-reuse always mode"
 
 feature ignore_unknown_macro
diff --git a/reg-tests/http-rules/acl_cli_spaces.vtc b/reg-tests/http-rules/acl_cli_spaces.vtc
index 8e0d273ba..8783f11a9 100644
--- a/reg-tests/http-rules/acl_cli_spaces.vtc
+++ b/reg-tests/http-rules/acl_cli_spaces.vtc
@@ -1,3 +1,4 @@
+#EXCLUDE_TARGETS=osx
 varnishtest "haproxy ACL, CLI and mCLI spaces"
 feature ignore_unknown_macro
 
diff --git a/reg-tests/mcli/mcli_debug_dev.vtc b/reg-tests/mcli/mcli_debug_dev.vtc
index 5fdf9c5ec..0ecaa6202 100644
--- a/reg-tests/mcli/mcli_debug_dev.vtc
+++ b/reg-tests/mcli/mcli_debug_dev.vtc
@@ -1,3 +1,4 @@
+#EXCLUDE_TARGETS=osx
 varnishtest "Test master CLI multiple commands with export-mode"
 
 # This test only checks if the master CLI parsing with pipelined commands is working:
diff --git a/reg-tests/mcli/mcli_show_info.vtc b/reg-tests/mcli/mcli_show_info.vtc
index 0a286580c..5c1949fd3 100644
--- a/reg-tests/mcli/mcli_show_info.vtc
+++ b/reg-tests/mcli/mcli_show_info.vtc
@@ -1,3 +1,4 @@
+#EXCLUDE_TARGETS=osx
 varnishtest "Show info of process 1"
 
 feature ignore_unknown_macro
diff --git a/reg-tests/mcli/mcli_start_progs.vtc b/reg-tests/mcli/mcli_start_progs.vtc
index 51c70155b..5b5549aa6 100644
--- a/reg-tests/mcli/mcli_start_progs.vtc
+++ b/reg-tests/mcli/mcli_start_progs.vtc
@@ -1,3 +1,4 @@
+#EXCLUDE_TARGETS=osx
 varnishtest "Try to start a master CLI with 2 programs"
 #REGTEST_TYPE=bug
 feature cmd "command -v sleep"